No impairment of renal function has been observed after concurrent administration of large doses of Ceftriaxone (KEPTRIX) and loop diuretics (e.g. furosemide). There is no evidence that Ceftriaxone (KEPTRIX) increases renal toxicity of Aminoglycosides. Ceftriaxone (KEPTRIX) has the potential to increase the effects of anticoagulants and to cause a disulfiram-like reaction with alcohol. Unlike many cephalosporins, probenecid does not affect the renal excretion of Ceftriaxone (KEPTRIX).