There have been rare reports of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Mild to moderate hearing loss has been reported in some children given Cefuroxime for the treatment of meningitis.
Kefsyn 750: Cefuroxime is generally well tolerated. Adverse reactions have been generally mild and transient in nature.
Local reactions: Transient pain at the site of intramuscular injection, which is more likely to occur with higher doses.
Hypersensitivity reactions: Skin rashes (maculopapular and urticaria), drug fever and very rarely anaphylaxis have been reported.
Gastrointestinal: Diarrhea and nausea. Pseudomembranous colitis may occur during or after treatment.
Blood: Decreased hemoglobin concentration and/or eosinophilia, leukopenia and neutropenia may occur. As with other cephalosporins, there have been very rare reports of thrombocytopenia.
Hepatic: Transient rise in serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT), and bilirubin may occur.
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