Kardiostan Adverse Reactions

Treatment with angiotensin II receptor antagonists is associated with dizziness and headache. Hypotension, characterized as orthostatic and dose-related, was seen in patients with volume depletion eg, those receiving high-dose diuretics.
Other adverse effects associated with the use of losartan include gastrointestinal disturbance, fatigue, muscle and joint pains, congestion, hyperkalemia, back pain, vertigo, migraine, acute pancreatitis and increase in liver enzymes. Losartan causes cough to a lesser degree than that of ACE inhibitors.
Hypersensitivity reactions eg, rash, urticaria, pruritus and angioedema have been reported with the use of losartan. There were also reports of immune thrombocytopenia, hepatotoxicity, rhabdomyolysis, anaphylactic reactions and vasculitis including Henoch-Schonlein purpura.
Atypical cutaneous lymphoid infiltrates, psoriasis, exacerbation and taste disturbance were reported in patients taking losartan but disappeared after cessation of Kardiostan.
Symptomatic anemia and decreased hemoglobin concentrations have been reported in patients with renal impairment.
There is no significant difference found between the adverse effects for children as compared to those reported in adults.