Jardiance Duo Dosage/Direction for Use

Adults with normal renal function (GFR ≥90 mL/min): The dosage should be individualised on the basis of the patient's current regimen, effectiveness, and tolerability. The maximum recommended daily dose of Empagliflozin + Metformin HCl (JARDIANCE DUO) is 25 mg of empagliflozin and 2000 mg of metformin (see Table 16 for additional dosing information).
In patients not adequately controlled on metformin alone or in combination with other products, including insulin, the recommended starting dose of Empagliflozin + Metformin HCl (JARDIANCE DUO) should provide empagliflozin 5 mg twice daily (10 mg total daily dose) and the dose of metformin similar to the dose already being taken. In patients tolerating a total daily dose of empagliflozin 10 mg, the dose can be increased to a total daily dose of empagliflozin 25 mg.
Patients already treated with empagliflozin should continue to take the same daily dose of empagliflozin.
Patients switching from separate tablets of empagliflozin (10 mg or 25 mg total daily dose) and metformin to Empagliflozin + Metformin HCl (JARDIANCE DUO) should receive the same daily dose of empagliflozin and metformin already being taken or the nearest therapeutically appropriate dose of metformin.
When Empagliflozin + Metformin HCl (JARDIANCE DUO) is used in combination with a sulphonylurea and/or insulin, a lower dose of sulphonylurea and/or insulin may be required to reduce the risk of hypoglycaemia (see Interactions and Adverse Reactions).
The recommended dose is one tablet twice daily.
For the different doses of metformin, Empagliflozin + Metformin HCl (JARDIANCE DUO) is available in strengths of 5 mg empagliflozin plus 500 mg or 1000 mg metformin hydrochloride or 12.5 mg empagliflozin plus 500 mg or 1000 mg metformin hydrochloride.
Empagliflozin + Metformin HCl (JARDIANCE DUO) should be given with meals to reduce the gastrointestinal undesirable effects associated with metformin.
Renal impairment: No dose adjustment recommended for patients with mild renal impairment.
An eGFR should be assessed before initiation of treatment with metformin containing products and at least annually thereafter. In patients at increased risk of further progression of renal impairment and in the elderly, renal function should be assessed more frequently, e.g. every 3-6 months.
For dosing recommendations in the paediatric population, see Paediatric population as follows. (See Table 16.)

Click on icon to see table/diagram/image

Missed dose: If a dose is missed, it should be taken as soon as the patient remembers. However, a double dose should not be taken at the same time. In that case, the missed dose should be skipped.
Paediatric population: The dosage should be individualised on the basis of the patient's current regimen, effectiveness, and tolerability. The recommended dose is one tablet twice daily.
The maximum recommended daily dose of Empagliflozin + Metformin HCl (JARDIANCE DUO) is 25 mg of empagliflozin and 2000 mg of metformin. (See general information as previously mentioned).
No data are available for children with eGFR <60 mL/min/1.73 m² and children below 10 years of age.