Isoptin/Isoptin SR Dosage/Direction for Use

Posology: Verapamil hydrochloride (Isoptin) Film-Coated Tablet/(Isoptin SR) Sustained-Release Tablet: The dose of verapamil hydrochloride should be adjusted individually in accordance with the severity of disease. Long-standing clinical experience shows that the average daily dose in all indications is between 240 mg and 360 mg. The daily dose should not exceed 480 mg on a long-term basis, although a higher dose may be used for a short period. There is no limitation on the duration of use. Verapamil hydrochloride should not be discontinued abruptly after long-term use. It is recommended to taper the dosage.
Verapamil hydrochloride 40 mg tablets should be used for patients likely to display a satisfactory response to low doses (e.g., patients with hepatic dysfunction or elderly patients). For patients requiring higher dosages (e.g., 240 mg to 480 mg verapamil hydrochloride per day), formulations with a more suitable active drug content should be used.
Adults: Coronary artery disease, paroxysmal supraventricular tachycardia, atrial flutter and atrial fibrillation: IR: 120 to 480 mg in three or four divided doses.
SR: 120 to 480 mg in one or two divided doses.
Hypertension: IR: 120 to 480 mg in three divided doses.
SR: 120 to 480 mg in one or two divided doses.
Special Populations: Pediatric population: The safety and efficacy of verapamil hydrochloride have been established in children: Up to age 6 years: 80 mg to 120 mg Verapamil hydrochloride (Isoptin) in two to three divided doses.
Age 6-14 years: 80 mg to 360 mg Verapamil hydrochloride (Isoptin) in two to four divided doses.
Renal impairment: Currently available data are described in Precautions. Verapamil hydrochloride should be used cautiously and with close monitoring in patients with impaired renal function.
Liver impairment: In patients with impaired liver function, metabolism of the drug is delayed to a greater or lesser extent depending on the severity of hepatic dysfunction, thus potentiating and prolonging the effects of verapamil hydrochloride. Therefore, the dosage needs to be adjusted with special caution in patients with impaired liver function and low doses should be given initially (see Precautions).
Method of administration: For oral use only.
Tablets should be taken without sucking or chewing, with sufficient liquid, preferably with or shortly after meals.