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Combinations containing any of the following medications, depending on the amount present, may also interact with this medication.
Diuretics (concurrent use with Irbesartan may have additive hypotensive effects).
Medications that inhibit the cytochrome P450 2C9 isoenzyme or medications that are metabolized by cytochrome P450 2C9 (the isoenzyme responsible for Irbesartan metabolism), such as Tolbutamide (in vitro studies show that Irbesartan metabolism may be affected by medications that are metabolized by or inhibit the cytochrome P450 2C9 isoenzyme, although no clinically relevant interactions have been observed).
