innohep Dosage/Direction for Use

175 anti-Xa IU/kg body weight given subcutaneously once daily.
Oral anticoagulation should be commenced on the second day of treatment.
175 anti-Xa IU/kg body weight once daily for at least 6 days and until adequate oral anti-coagulation is established.
Prefilled syringes: The Tinzaparin sodium (innohep) syringes have a graduation of 0.05 mL which makes it possible to choose the most suitable syringe for the individual patient depending on the patient's body weight. In order to achieve the correct dosage for the individual patient the average volume is ejected before s.c. injection holding the syringe in a vertical position.
Different low molecular weight heparins are not necessarily equivalent. Therefore, specific posology and instructions for use of each one should be followed.
Children: There is no experience of use in children.
Elderly: Renal function should be assessed with e.g. the Cockcroft-Gault formula to estimate creatinine clearance levels.
No dose reduction is needed in elderly patients with normal renal function.
Renal impairment: No dose reduction is needed in patients having creatinine clearance levels down to 20 mL/min. However, precaution is recommended when treating patients with severe renal impairment (creatinine clearance < 30 mL/min).