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Probenecid causes almost 2-fold reduction in clearance of paracetamol by inhibiting its conjugation with glucuronic acid. A reduction in the paracetamol dose should be considered if it is to be used concomitantly with probenecid.
Salicylamide may prolong the elimination t½ of paracetamol.
Caution should be taken with concomitant intake of enzyme-inducing substances.
Concomitant use of paracetamol (4 g daily for at least 4 days) with oral anticoagulants may lead to slight variation of international normalised rate (INR) values. In this case, increased monitoring of INR values should be conducted during the period of concomitant use as for 1 week after paracetamol treatment has been discontinued.
