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Hypersensitivity to the active substance, or to any of the excipients.
Second and third trimester of pregnancy.
Lactation.
The concomitant use of irbesartan with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (glomerular filtration rate (GFR) <60 mL/min/1.73 m2).
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