I.V.-Globulin SN Adverse Reactions

Shock: Symptoms of shock may occur. If dyspnea, wheeze, chest pain, hypotension or weak pulse are watched, administration should be discontinued, and 0.1~0.5 mL epinephrine (1:1,000) or the administration of cortisone should be considered.
Circulatory: Rapid administration can cause hypotension. (Caution should be taken to patients with A-/Hypogammaglobulinemia.)
Liver: Liver function disorders or jaundice accompanying and increase in ALT or AST may occur. Caution should be taken, and proper treatment should be followed if needed.
Kidney: It has been reported in the literature that acute renal failure may occur with the use of immune globulin (human) products. If dehydration, hypouresis, increase of creatinine or increase of BUN, etc. are observed, administration should be discontinued, and proper treatment should be taken.
The administration dosage and rate should be lowered (as low as possible) for patients at high risk of acute renal failure.
Central Nervous System: Aseptic meningitis from a large volume of I.V.-Globulin SN inj. administration (Nuchal rigidity, fever, headache, nausea, vomiting, mental fog, etc.) may occur. In these cases, administration should be discontinued and proper treatment taken.
Blood: Because a decrease in platelets may occur with the administration of I.V.-Globulin SN inj., caution should be taken. If this symptom occurs, proper treatment should be taken.
Other possible undesirable effects: Drowsiness, chill, chest pain, abdominal pain, gluteal pain and anxiety etc.