Hi-Perazone Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Cefoperazone Na 1 g, sulbactam Na 500 mg

Indications/Uses

Upper & lower resp tract infections & UTI; peritonitis, cholecystitis, cholangitis, & other intra-abdominal infections; septicemia; meningitis; skin & soft tissue infections; bone & joint infections; pelvic inflammatory disease, endometritis, gonorrhea, & other genital tract infections.

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Dosage/Direction for Use

IV/IM Adult 2-4 g/day (ie, 1-2 g/day each) in equally divided doses every 12 hr. Severe or refractory infections May be increased up to 8 g (ie, 4 g/day each) in equally divided doses every 12 hr. Max dose: Sulbactam 4 g daily (8 g of the combination). Childn 40-80 mg/kg/day (20-40 mg/kg/day each) every 6-12 hr. Serious or refractory infections May be increased up to 240 mg/kg/day (160 mg/kg/day cefoperazone activity) administered in 2-4 equally divided doses. Neonate up to 1 wk Max daily dose: Not to exceed sulbactam 80 mg/kg/day every 12 hr. Renal impairment CrCl 15-30 mL/min Max: Sulbactam 1 g every 12 hr, <15 mL/min Max: Sulbactam 500 mg every 12 hr. Severe biliary obstruction, severe hepatic disease or coexistent w/ renal dysfunction Do not exceed cefoperazone 2 g/day.

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Overdosage

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Contraindications

Hypersensitivity to penicillins, sulbactam, cefoperazone or cephalosporins.

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Special Precautions

Discontinue use if allergic reaction occurs. Overgrowth of non-susceptible organism due to prolonged use. Severe biliary obstruction &/or hepatic disease or coexistent w/ renal dysfunction. Pregnancy & lactation. Premature infants & neonates.

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Use In Pregnancy & Lactation

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Adverse Reactions

Neutropenia, leukopenia, +ve Coombs direct test, decreased Hb & haematocrit, thrombocytopenia; increased ALT & AST, increased blood alkaline phosphatase. Coagulopathy, eosinophilia; diarrhea, nausea; vomiting, increased blood bilirubin.

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Drug Interactions

Avoid ingestion of alcohol beverages & use of ethanol containing soln.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Hi-Perazone detailed prescribing information

Storage

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Description

View Hi-Perazone description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Cephalosporins

ATC Classification

J01DD62 - cefoperazone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Hi-Perazone powd for inj

Packing/Price

(vial) 1's

Hi-Perazone

cefoperazone + sulbactam

Manufacturer:

Swiss Parenterals Ltd

Distributor:

HLM Pharma

Marketer:

Ambica