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Docetaxel is for IV infusion. All patients should be premedicated with oral corticosteroids eg, dexamethasone 16 mg/day for 3 days starting 1 day prior to docetaxel administration in order to prevent allergic reaction and fluid retention.
Withdraw corresponding diluent of docetaxel into appropriate solution before use. Shake gently and mix well. Allow the vial to stand at room temperature for 5 min. Check whether the solution is clear. Then according to dosage, withdraw mixed solution to a syringe and inject into an infusion bag or bottle of 5% dextrose solution or 0.9% sodium chloride solutions. Shake gently and mix well to produce a final concentration not more than 0.9 mg/mL. The recommended dose for docetaxel is 75 mg/m2 administered over 1 hr every 3 weeks.
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