Gyraxen Side Effects

Side effects from long term treatment are mainly associated with the anti-oestrogenic action of the drug such as hot flushes, vaginal bleeding and pruritus vulvae. Other side effects which may occur are gastro-intestinal upsets, tumour pain, light headedness, dizziness, rashes and occasionally fluid retention.
These side effects may be controlled by reduction of dosage without loss of control of the disease but if they are not, then it may be necessary to stop treatment.
Transient falls in platelet count, to levels 80,000 to 90,000, but occasionally lower, have been reported in patients taking Tamoxifen for breast cancer. These have not been associated with a haemorrhagic tendency and the platelet counts have recovered notwithstanding continuing treatment.
Tamoxifen citrate should be used with caution in patients with factors predisposing them to thromboembolism. A small number of endometrial hyperplasia, endometrial polyps and endometrial carcinomas have been reported in association with Tamoxifen treatment. A definitive relationship to Tamoxifen therapy has not been established.
A number of cases of visual disturbance including corneal changes, cataracts and retinopathy have been described in patients receiving Tamoxifen therapy.
Use in Pregnancy: Tamoxifen citrate must not be given during pregnancy.