Gynomax Dosage/Direction for Use

Do not use without consulting a physician. If it is not advised otherwise by a physician, 1 suppository should be inserted high into the vagina at night for 3 days. It is not advised to be used twice a day by no means. Administration during menstrual period is not recommended due to impaired efficacy and difficulty of administration.
Suppositories should be inserted in lying position high into the vagina. If possible, do not stand up for half an hour after placing the suppository.
Only for intravaginal use. Not to be swallowed or applied by other routes.
Additional Information on Special Populations: Elderly (over 65 years): Same as for younger adults.
Should not be used in children under 12 years old.
Renal/Liver failure: No significant changes in the pharmacokinetic parameters (CrCl <22 mL/min.) of tinidazole were found in patients with severe renal failure. Therefore, dosage adjustment is not necessary in patients with that condition. Clearance of tinidazole increases significantly during hemodialysis and the half-life reduces from 12 hours to 4.9 hours. During a 6-hour dialysis procedure, 43% of the available tinidazole was eliminated. If tinidazole will be applied before hemodialysis, the administration of half-dose of recommended tinidazole after hemodialysis is advised.
There is no data about the pharmacokinetic of tinidazole for the patients with hepatic failure. Recommended dose of tinidazole must be administered carefully in patients with hepatic failure.
Lidocaine half-life may be prolonged two folds or more in patients with hepatic failure. Renal failure does not affect the pharmacokinetics of lidocaine, however it may increase the accumulation of metabolites. These characteristics should be taken in consideration by patients with hepatic and/or renal failure who will use Tioconazole + Tinidazole + Lidocaine (Gynomax).