Goofice Special Precautions

Precaution Concerning Indication: No clinical experience of use in drug-induced and disease-induced constipations.
Precaution Concerning Dosage and Administration: Elobixibat (GOOFICE) may cause abdominal pain or diarrhea; dose reduction, drug withdrawal, or discontinuation should be considered depending on the patient's symptoms, and the need for continuing treatment with Elobixibat (GOOFICE) should be carefully evaluated on a regular basis to avoid continuing aimless administration.
Careful Administration (Elobixibat should be administered with care in the following patients): Patient with serious liver disorder. Elobixibat (GOOFICE) may fail to achieve its expected efficacy in patients with biliary obstruction or reduced bile acid secretion, etc.
Precaution Concerning Use: Precaution Concerning the Dispensing of the Drug: Patients who are given drugs supplied in PTP package must be instructed to remove the drugs from the PTP sheet before taking drugs. [It has been reported that, if the PTP sheet is swallowed, the sharp corners of the sheet may puncture the esophageal mucosa causing perforation and resulting in serious complications, such as mediastinitis.]
Drug Compatibility: Because there are no studies on drug compatibility, do not mix this drug with other drugs.
Effects on Ability to Drive, Operate Machinery: There is no evidence of drug effects on the ability to drive or operate machinery.
Use in Children: Safety has not been established in low-birth-weight infants, neonates, nursing infants, infants, or pediatric patients (no clinical experience).
Use in the Elderly: Since the elderly generally have reduced physiological functions, cautions should be exercised, such as reducing the dose.