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Pharmacology: Pharmacodynamics: Glimepiride acts mainly by stimulating insulin release from pancreatic beta cells. As with other sulphonylureas, this effect is based on an increase of responsiveness of the pancreatic beta cells to the physiological glucose stimulus. Glimepiride increases the activity of the glycosylphosphatidyl inositol specific phospholipase C which may be correlated with the drug induced lipogenesis and glycogenesis in isolated fat and muscle cells.
Pharmacokinetics: Glimepiride is completely absorbed from the gastrointestinal tract, with peak plasma concentration occurring within 2 to 3 hours. It is highly bound to plasma proteins. The drug is extensively metabolized to two main metabolites, a hydroxyl derivative and a carboxyl derivative. The half-life after multiple doses is about 9 hours. Approximately 60% of a dose is being eliminated in the urine and 40% in the feces.
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