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Overdose with domperidone has been reported primarily in infants and children. Symptoms of overdosage may include agitation, altered consciousness, convulsion, disorientation, somnolence and extrapyramidal reactions.
There is no specific antidote to domperidone overdose. In the event of an overdose, standard symptomatic treatment should be given immediately. Gastric lavage within one hour of ingestion as well as activated charcoal may be useful. Electrocardiogram (ECG) monitoring should be done due to the possibility of QT interval prolongation. Anticholinergics and anti-Parkinsonian agents may be helpful in controlling the extrapyramidal reactions.
