Genvac-B Description

GENVAC-B (Hepatitis B vaccine (Recombinant DNA)) is a non infectious recombinant DNA Hepatitis B vaccine. It contains purified surface antigen of the virus obtained by culturing genetically-engineered Hansenula polymorpha yeast cells having the surface antigen gene of the Hepatitis B virus. The Hepatitis B surface antigen (HBsAg) expressed in the cells of Hansenula polymorpha is purified through several chemical steps and formulated as a suspension of the antigen adsorbed on aluminium hydroxide and thiomersal is added as preservative. The vaccine does not contain any material of human or animal origin. The vaccine meets the requirements of W.H.O. when tested by the methods outlined in W.H.O., TRS 978 (2013).
Composition: Paediatric: Each dose of 0.5 mL contains: 10 mcg of purified Hepatitis B surface antigen, Adsorbed on Aluminium hydroxide (Al⁺⁺⁺) 0.25 mg to 0.40 mg.
Preservative: Thiomersal 0.005%.
Produced in Hansenula polymorpha (yeast).
Dose: 0.5 mL by intramuscular injection.
Adult: Each dose of 1 mL contains: 20 mcg of purified Hepatitis B surface antigen, Adsorbed on Aluminium hydroxide (Al⁺⁺⁺) 0.50 mg to 0.80 mg.
Preservative: Thiomersal 0.005%.
Produced in Hansenula polymorpha (yeast).
Dose: 1 mL by intramuscular injection.