Gemvex-200/Gemvex-1000 Drug Interactions

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Full Prescribing Info

Drug Interactions

When Gemcitabine (1250 mg/m² on Days 1 and 8) and cisplatin (75 mg/m² on Day 1) were administered in patients, the clearance of Gemcitabine on Day 1 was 128 L/hr/m² and on Day 8 was 107 L/hr/m². The clearance of cisplatin in the same study was reported to be 3.94 mL/min/m² with a corresponding half-life of 134 hours. Analysis of data from metastatic breast cancer patients shows that, on average, Gemcitabine has little or no effect on the pharmacokinetics (clearance and half-life) of paclitaxel and paclitaxel has little or no effect on the pharmacokinetics of Gemcitabine. However, due to wide confidence intervals and small sample size, interpatient variability may be observed.

Gemvex-200/Gemvex-1000 Drug Interactions

gemcitabine

Manufacturer:

Vexxa Lifesciences

Distributor:

VE Pharma