The most common side effects associated with Furosemide therapy is fluid and electrolyte imbalance including hyponatremia, hypokalemia, and hypochloraemic alkalosis, particularly after large doses or prolonged administration. Because of their shorter duration of action, the risk of hypokalemia maybe less with loop diuretics such as Furosemide than with thiazide diuretics, Furosemide increases the urinary excretion of calcium. Nephrocalcinosis has been reported when Furosemide has been used to treat preterm infants.