Ketoconazole is not for ophthalmic use. Irritation may occur when Ketoconazole is used immediately after prolonged treatment with topical corticosteroids. Therefore, to prevent a rebound effect after stopping a prolonged treatment with topical corticosteroids, it is recommended to continue applying a mild topical corticosteroid in the morning and apply Ketoconazole in the evening, and to subsequently and gradually withdraw the steroid therapy over a period of 2-3 weeks. Ketoconazole has been shown to be teratogenic in animals.