Fucidin H Mechanism of Action

Pharmacotherapeutic Group: Corticosteroids, weak, combinations with antibiotics. ATC code: D07 CA01.
Pharmacology: Pharmacodynamics and Pharmacokinetics: Fucidin H Cream combines the potent topical antibacterial action of fusidic acid with the anti-inflammatory and antipruritic effects of hydrocortisone. Fusidic acid and its salts exhibit fat and water solubility properties with strong surface activity, and show unusual ability to penetrate intact skin.
Concentrations of 0.03 - 0.12 mcg/ml inhibit nearly all strains of Staphylococcus aureus. Topical Fucidin is also active against Streptococci, Corynebacteria, Neisseria and certain Clostridia.
There are no data which define the pharmacokinetics of Fucidin H Cream, following topical administration in man. However, in vitro studies show that fusidic acid can penetrate intact human skin. The degree of penetration depends on factors such as the duration of exposure to fusidic acid and the condition of the skin. Fusidic acid is excreted mainly in the bile with little excreted in the urine. Hydrocortisone is absorbed following topical administration. The degree of absorption is dependent on various factors including skin condition and site of application. Absorbed hydrocortisone is extensively metabolised and rapidly eliminated in the urine.
Properties: Fucidin H Cream combines the antibacterial action of fusidic acid with the anti- inflammatory effect of hydrocortisone acetate.