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Usual Adult Dose: 1-2 g given once daily depending on the type and severity of infection. Maximum Dose: 4g/day. Treatment of Uncomplicated Nongonococcal Infections: Single IM dose of 250 mg is recommended. Surgical Prophylaxis: Single IV dose of 1 g is recommended ½-2 hrs before surgery.
Usual Pediatric Dose: Infants and Children <12 years: Mild to Moderate Infections: 50-75 mg/kg body weight/day given once daily. Maximum Dose: 2 g/day. Severe Infections (ie, meningitis, septicemia, sepsis neonaforum): 100 mg/kg body weight given once daily. Maximum Dose: 4 g/day.
Click on icon to see table/diagram/imagePatient Information: Usual duration of ceftriaxone therapy is 4-14 days, but complicated infections may require prolonged treatment. For most infections, except gonorrhea, continue therapy for at least 48 hrs after the patient become asymptomatic or evidence of bacterial eradication has been obtained. When treating infections caused by Streptococcus pyogenes, continue therapy for at least 10 days.
Renal Impairment: No dosage adjustment is required in patients with impaired renal function. However, monitor blood levels in patients with severe renal impairment and in patients with both renal and hepatic dysfunctions.
Administrations: IM: Dissolve 250-mg or 500-mg powder for injection in 2 mL, and 1g in 3.5 mL of 1% lidocaine solution and administer by deep intragluteal injection. Ceftriaxone and lidocaine solution must never be administered IV.
IV: Dissolve 250-mg powder for injection in 2 mL, and 500 mg and 1 g in 5 mL water for injection. Administer by IV injection for 2-4 min.
IV Infusion: Ceftriaxone should be administered by IV infusion over a period of 30 min. Dissolve 1-g powder for injection in 40 mL in one of the following calcium-free infusion solutions: 0.9% Sodium Chloride Solution; 0.45% Sodium Chloride + Dextrose 2.5% Solution; Dextrose 5%; Dextrose 10% Solution; Levulose 5% Solution; Dextran 6% Dextrose Solution, Sterile Water for Injections.
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