Foliage Mechanism of Action

Pharmacology: Pharmacokinetics: Folic acid is rapidly absorbed from the gastrointestinal tract, mainly from the duodenum and jejunum. Dietary folates are stated to be less well absorbed than crystalline folic acid. The naturally occurring folate polyglutamates are largely deconjugated and reduced by dihydrofolate reductase in the intestines to form 5-methyltetrahydrofolate, which appears in the portal circulation, where it is extensively bound to plasma proteins. Folic acid administered therapeutically enters the portal circulation largely unchanged since it is a poor substrate for reduction by dihydrofolate in the plasma and liver.
The principal storage site of folate is the liver; it is also actively concentrated in the CSF. Folate metabolites are eliminated in the urine. Folate is distributed into breast milk. Folic acid is removed by haemodialysis.