Foliage Max Mechanism of Action

Pharmacology: Mechanism of Action: Folic Acid, Thiamine Nitrate (B1), Pyridoxine HCl (B6) and Mecobalamin (B12) are members of the Vitamin B group. All are essential cofactors for various metabolic processes including the synthesis of purine and pyrimidine nucleotides and hence in the synthesis of DNA.
Folic Acid, also known as folate, is essential in cell division and DNA synthesis. Folic Acid is rapidly absorbed from the gastrointestinal tract, mainly from the duodenum and jejunum. Dietary folates are stated to be less well absorbed than crystalline folic acid. The naturally occurring folate polyglutamates are largely deconjugated and reduced by dihydrofolate reductase in the intestines to form 5-methyltetrahydrofolate, which appears in the portal circulation, where it is extensively bound to plasma proteins. Folic Acid administered therapeutically enters the portal circulation largely unchanged since it is a poor substrate for reduction by dihydrofolate in the plasma and liver. The principal storage site of folate is the liver. It is also actively concentrated in the CSF. Folate metabolites are eliminated in the urine. Folate is distributed into breast milk. Folic acid is removed by haemodialysis.
Thiamine is primarily involved in energy production in the body especially in the brain. Vitamin B6 is particularly important in the formation of body proteins and structural compounds. Vitamin B12 is involved in many body processes and works very closely with folic acid. Folic Acid and Vitamin B12 help cells to multiply and are important cofactors for the remethylation of homocysteine to methionine, hence in lowering plasma homocysteine levels.