Flutizal Overdosage

No human overdosage data has been reported for this combination inhaler; however data on overdose with both drugs are given as follows.
Salmeterol: The signs and symptoms of Salmeterol overdose are seizures, angina, hypertension or hypotension, tachycardia, arrhythmias, nervousness, headache, tremor, muscle cramps, dry mouth, palpitation, nausea, dizziness, fatigue, malaise, and insomnia.
Other signs of overdosage may include hypokalemia and hyperglycemia. Treatment consists of discontinuation of Salmeterol together with appropriate cardio selective beta-blocking agents, which should be used with caution in patients with a history of bronchospasm.
Fluticasone propionate: Acute inhalation of Fluticasone propionate doses in excess of those recommended may lead to temporary suppression of adrenal function. This does not need emergency action as adrenal function is recovered in a few days, as verified by plasma cortisol measurements. Chronic overdose of inhaled Fluticasone propionate may lead to adrenal suppression. Monitoring of adrenal reserve may be necessary. In cases of Fluticasone propionate overdose this combination inhaler therapy may still be continued at a suitable dosage for symptom control.