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Pharmacology: Pharmacodynamics: Mechanism of Action: Fluticasone propionate is a synthetic, trifluorinated corticosteroid with anti-inflammatory activity.
Fluticasone propionate was 3-fold to 5-fold more potent than dexamethasone in these assays.
Pharmacokinetics: Fluticasone propionate is poorly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism; oral bioavailability is reported to be only about 1%.
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