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The actions of supplemental Glucosamine may play a role in the promotion and maintenance of the structure and function of cartilage in the joints of the body. It may also have anti-inflammatory properties.
Pharmacokinetics: About 90% of Glucosamine administered orally as a Glucosamine salt gets absorbed from the small intestine, and from there it is transported via the portal circulation to the liver, with only 10% appearing in the feces. It appears that a significant fraction of the ingested Glucosamine is catabolized by first-pass metabolism in the liver. The absorbed Glucosamine, 25% will be excreted in the urine, 65% excreted as exhaled carbon dioxide, with the remaining 10% retained in the tissues.
