Although no major arrhythmias have been documented with Doxofylline, the occurrence of major cardiac rhythm disturbances cannot be excluded in case of over dosage of xanthine compounds. If a potential oral overdose is established the patient may present seizures: these symptoms could be the first sign of intoxication. Adverse reactions may cause the withdrawal from treatment. A lower dose re-challenge may start only after the advice of the physician. There is no specific antidote: it is suggested that the management principles should be instituted according to a symptomatic relief of cardio-circulatory shock.
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