Ferriscript Dosage/Direction for Use

Adults and the Elderly: The total cumulative dose of Iron sucrose Injection USP, equivalent to the total iron deficit (mg), is determined by the haemoglobin level and body weight. The dose for Iron sucrose Injection USP must be individually determined for each patient according to the total iron deficit calculated with the following formula: (See equation.)

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The total amount of Iron sucrose Injection USP required is determined from previous calculation.
Alternatively, the total amount of Iron Sucrose Injection USP required in mL is determined from the following formula or dosage table. (See equation.)

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Maximum recommended dose: The total single dose must not exceed 200 mg of iron given not more than three times per week. If the total necessary dose exceeds the maximum allowed single dose, then the administration has to be split.
Children: The use of Iron sucrose Injection USP has not been adequately studied in children and, therefore, Iron sucrose Injection USP is not recommended for use in children.
Administration: Iron sucrose Injection USP must only be administered by the intravenous route. This may be by a slow intravenous injection or by an intravenous drip infusion.
Before administering the first dose to a new patient, a test dose of Iron sucrose Injection USP should be given. Iron sucrose Injection USP must not be used for intramuscular injection.
INTRAVENOUS DRIP INFUSION: Iron sucrose Injection USP must be diluted only in sterile 0.9% w/v sodium chloride solution: 5 mL Iron sucrose Injection USP (100 mg iron) in max. 100 mL sterile 0.9% w/v sodium chloride solution.
10 mL Iron sucrose Injection USP (200 mg iron) in max. 200 mL sterile 0.9% w/v sodium chloride solution.
For stability reasons, dilutions to lower Iron sucrose Injection USP concentrations are not permissible.
Dilution must take place immediately prior to infusion and the solution should be administered as follows: 100 mg iron (5 mL Iron sucrose Injection USP) in at least 15 minutes.
200 mg iron (10mL Iron sucrose Injection USP) in at least 30 minutes.
The first 25 mg of iron (i.e. 25 mL of solution) should be infused as a test dose over a period of 15 minutes. If no adverse reactions occur during this time then the remaining portion of the infusion should be given at an infusion rate of not more than 50 mL in 15 minutes.
INTRAVENOUS INJECTION: Iron sucrose Injection USP may be administered by slow intravenous injection at a rate of 1 mL undiluted solution per minute (i.e. 5 minutes per ampoule) and not exceeding 2 ampoules Iron sucrose Injection USP (200 mg iron) per injection.
Before administering a slow intravenous injection, a test dose of 1 mL (20 mg of iron) should be injected slowly over a period of 1 to 2 minutes. If no adverse events occur within 15 minutes of completing the test dose, then the remaining portion of the injection may be given.
Injection into Dialyser: Iron sucrose Injection USP may be administered during a hemodialysis session directly into the venous limb of the dialyser under the same procedures as those outlined for intravenous injection.