Hypercholesterolemia: Fenostat is indicated as an adjunct to diet to reduce elevated total-C, LDL-C, apoB and to increase HDL-C in adult patients with primary hypercholesterolemia.
Lipid altering agents should be used in addition to diet restricted in saturated fat and cholesterol only when the response to diet and other non-pharmacological measures has been inadequate. (See Table 1.)

After the LDL-C goal has been achieved, if the TG level is still ≥200 mg/dL, non-HDL-C (TC minus HDL-C) becomes a secondary target of therapy. Non-HDL-C goals are set 30 mg/dL higher than LDL-C goals for each risk category.