Dizziness, fatigue, flushing, headache, hypotension and peripheral edema may occur. Gastrointestinal disturbances, as well as eye pain, increased micturition frequency, lethargy, and mental depression have also been reported. At the start of treatment a paradoxical increase in ischemic chest pain may occur. In a few patients an excessive fall in blood pressure has led to cerebral or myocardial ischemia or transient blindness. There have been reports of abnormalities in liver function, fever and rashes due to hypersensitivity reactions. Gingival hyperplasia has been reported but is often reversible on drug withdrawal. Sexual dysfunction/impotence occurs rarely.