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Theophylline: Febuxostat altered the metabolism of theophylline (a substrate of XO) in humans. Therefore, use with caution when coadministering Febuxostat with theophylline.
Azathioprine or Mercaptopurine: Drug interaction studies of Febuxostat with other drugs that are metabolized by XO (e.g., mercaptopurine and azathioprine) have not been conducted. Inhibition of XO by Febuxostat may cause increased plasma concentrations of these drugs leading to toxicity. Febuxostat is contraindicated in patients being treated with azathioprine or mercaptopurine.
Other Drug Interaction: Febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine. Therefore, Febuxostat may be used concomitantly with these medications.
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