Discontinue use if serious allergic/hypersensitivity reactions, including SJS, occur. Not recommended in patients w/ ischemic heart disease or CHF; patients in whom rate of urate formation is greatly increased eg, malignant disease & its treatment, Lesch-Nyhan syndrome; organ transplant recipients. Not to be started until an acute attack of gout has completely subsided. Flare prophylaxis w/ NSAID or colchicine at treatment initiation for at least 6 mth is recommended. Patients w/ alteration of thyroid function. Perform LFT prior to initiation of therapy & periodically thereafter. Not recommended in concomitant use w/ mercaptopurine/azathioprine. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Severe renal impairment (CrCl <30 mL/min). Severe hepatic impairment (Child Pugh class C). Not to be used during pregnancy & lactation. Childn <18 yr.
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