Eylea Caution For Usage

Incompatibilities: Aflibercept (Eylea) must not be mixed with other medicinal products.
Instructions for use/handling: The vial is for single use in one eye only. Extraction of multiple doses from a single vial or pre-filled syringe may increase the risk of contamination and subsequent infection.
Prior to administration visually inspect the solution for injection. Do not use the vial if particulates, cloudiness, or discoloration are visible.
Prior to usage, the unopened vial of Aflibercept (Eylea) may be stored at room temperature (25°C/77°F) for up to 24 hours. After opening the vial, proceed under aseptic conditions.
For the intravitreal injection, a 30 G x ½ inch injection needle should be used.
Vials: 1. Remove the plastic cap and disinfect the outer part of the rubber stopper of the vial.
2. Attach the 18 G, 5-micron filter needle supplied in the carton to a 1-mL sterile, Luer-lock syringe.
3. Push the filter needle into the center of the vial stopper until the needle is completely inserted into the vial and the tip touches the bottom or bottom edge of the vial.
4. Using aseptic technique withdraw all of the Aflibercept (Eylea) vial contents into the syringe, keeping the vial in an upright position, slightly inclined to ease complete withdrawal. To deter the introduction of air, ensure the bevel of the filter needle is submerged into the liquid. Continue to tilt the vial during withdrawal keeping the bevel of the filter needle submerged in the liquid.
5. Ensure that the plunger rod is drawn sufficiently back when emptying the vial in order to completely empty the filter needle.
6. Remove the filter needle and properly dispose of it.
Note: Filter needle is not to be used for intravitreal injection.
7. Using aseptic technique, firmly twist a 30 G x ½ inch injection needle to the Luer-lock syringe tip.
8. Holding the syringe with the needle pointing up, check the syringe for bubbles. If there are bubbles, gently tap the syringe with finger until the bubbles rise to the top.
9. Eliminate all bubbles and expel excess drug by slowly depressing the plunger so that the plunger tip aligns with the line that marks 0.05 mL on the syringe.