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Cough Suppressant.
Pharmacology: Pharmacodynamics: Action: Levodropropizine, the (-)-(S)-isomer of dropropizine, is a cough suppressant with peripheral action. It decreases the excitability of tracheobronchial receptors thus suppressing the cough reflex.
Pharmacokinetics: Absorption: Rapidly absorbed from the gastrointestinal tract.
Bioavailability: >75%. Time to peak plasma concentration: 0.75 hours (range: 0.25-2 hours).
Distribution: Plasma protein binding: 11-14%.
Excretion: Via urine (35% as unchanged drug and metabolites). Elimination half-life: 2.3 ± 0.5 hours.
