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Exflem 200: No case of toxic overdose has been observed to date in association with oral pharmaceutical forms of acetylcysteine.
Volunteers were treated with a dose of 11.6 g acetylcysteine/day over 3 months without observing any severe adverse reactions. Oral doses up to 500 mg acetylcysteine /kg BW have been tolerated without any symptoms of intoxication.
Symptoms of intoxication: Overdoses may lead to gastrointestinal symptoms such as nausea, vomiting and diarrhoea. Infants are at risk of hypersecretion.
Therapeutic measures in case of an overdose: If necessary, according to the symptoms.
Experience gained from intravenous acetylcysteine treatment of paracetamol intoxication is available in humans with maximum daily doses of up to 30 g acetylcysteine. Intravenous administration of extremely high acetylcysteine concentrations led to partially irreversible "anaphylactoid" reactions, particularly in connection with rapid administration.
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