Exetas 25 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Exemestane

Indications/Uses

Adjuvant treatment of postmenopausal women w/ oestrogen receptor +ve invasive early breast cancer, following 2-3 yr initial adjuvant tamoxifen therapy. Advanced breast cancer in women w/ natural or induced postmenopausal status whose disease has progressed following antioestrogen therapy.

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Dosage/Direction for Use

Adult & elderly 25 mg daily.

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Overdosage

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Administration

Should be taken with food.

Contraindications

Hypersensitivity. Premenopausal women. Pregnancy & lactation.

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Special Precautions

Not to be administered to women w/ premenopausal endocrine status. Initiate monitoring & treatment for prophylaxis & osteoporosis in at risk patients. Assess bone mineral density in patients w/ advanced disease. Consider routine assessment of 25 hydroxy vit D levels prior to start of treatment due to high prevalence of severe deficiency in women w/ early breast cancer. May provide +ve result in doping control tests. Hepatic or renal impairment. Pregnancy. Do not administer in lactating women. Women of perimenopausal status or childbearing potential. Not recommended in childn.

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Use In Pregnancy & Lactation

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Adverse Reactions

Insomnia; headache; hot flushes; nausea; increased sweating; joint & musculoskeletal pain; fatigue. Anorexia; depression; dizziness, carpal tunnel syndrome, paraesthesia; abdominal pain, vomiting, constipation, dyspepsia, diarrhoea; rash, alopecia, urticaria, pruritus, osteoporosis, fracture, pain, peripheral oedema.

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Drug Interactions

Reduced AUC & C_max w/ rifampicin. Reduce efficacy in co-administration w/ rifampicin, anticonvulsants (eg, phenytoin & carbamazepine) & herbal prep containing St John's wort. Negate pharmacological action in concomitant use w/ oestrogen containing medicines.

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Storage

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Description

View Exetas 25 description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Cancer Hormone Therapy

ATC Classification

L02BG06 - exemestane ; Belongs to the class of enzyme inhibitors. Used in treatment of neoplastic diseases.

Regulatory Classification

Presentation/Packing

Form

Exetas 25 FC tab 25 mg

Packing/Price

30's

Exetas 25

exemestane

Manufacturer:

Intas

Distributor:

Accord Healthcare