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Gout flare: An increase in gout flares is frequently observed during initiation of anti-hyperuricemic agents including Febuxostat. If a gout flare occurs during treatment, Febuxostat need not be discontinued. Prophylactic therapy i.e., non-steroidal anti-inflammatory drug (NSAID) or colchicine upon initiation of treatment may be beneficial for up to six months.
Cardiovascular events: Monitor for signs and symptoms of MI and stroke & discuss with physician.
Liver enzyme elevation: Transaminase elevations have been observed in Febuxostat treated patients. Monitor liver function tests periodically.
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