Endmet Caution For Usage

Direction for Reconstitution: The vial of Leuprorelin Acetate (Prolide) containing sterile lyophilized microspheres should be reconstituted immediately prior to administration.
Since the product does not contain a preservative the suspension should be discarded if not used immediately. Leuprorelin Acetate (Prolide) should be administered as a single subcutaneous or intramuscular injection in accordance with the following directions: 1. Detach the flip cap from the Prolide vial and ampoule containing 2 mL diluent.
2. Using a syringe 21 gauge needle, withdraw 2 mL of diluent from the ampoule and inj vial of Leuprorelin Acetate using aseptic technique. Remove the syringe and keep aseptic.
3. Shake the vial gently for 15 to 20 seconds to thoroughly dispense the particles and to obtain a uniform milky suspension.
4. Immediately withdraw the entire contents of the vial into the syringe, change the needle on syringe with a 21 gauge needle and apply sterile dressing to injection site if required.
5. The injection should be given as soon as possible after mixing. If any settling of suspension occurs in vial or syringe, resuspended by gentle shaking and administer immediately.
No other fluid should be given for the reconstitution Leuprorelin acetate (Prolide).
How to use: Due to different release characteristics a fractional dose of the 3-month depot formulation is not equivalent to the same dose of the monthly formulation and should not be given.
1. Ensure that the fluid is at the bottom section of the diluent ampoule (flick or tap lightly if needed).
Hold the ampoule & Snap open.
2. Inject diluent into the vial.
3. Shake well for thorough dispersion.
4. The suspension will appear milky.
5. Inject the entire contents intramuscularly/subcutaneously.