Isoxsuprine hydrochloride.
Each tablet contains: Isoxsuprine (as hydrochloride) 10 mg.
Pharmacology: Pharmacodynamics: Mechanism of Action: Isoxsuprine is a vasodilator which also stimulates beta-adrenergic receptors. It causes direct relaxation of vascular and uterine smooth muscle and its vasodilating action is greater on the arteries supplying skeletal muscle than on those supplying skin. Isoxsuprine also produces positive inotropic and chronotropic effects.
Pharmacokinetics: Isoxsuprine hydrochloride is well absorbed from the gastrointestinal tract. The peak plasma concentration occurs about 1 hour after administration by mouth. A plasma half-life of 1.5 hours has been reported. Isoxsuprine is excreted in the urine mainly as conjugates.
Isoxsuprine hydrochloride has been used to arrest premature labour. It has also been given in the treatment of cerebral and peripheral vascular disease.
Initial dose of 10 mg to 20 mg three to four times daily. Or as prescribed by the physician.
lsoxsuprine is contra-indicated after recent arterial haemorrhage. It should not be given immediately post partum, nor should it be used for premature labour if there is infection. In women being treated for premature labour, the risk of pulmonary oedema means that extreme caution is required and the precautions and risk factors discussed under Salbutamol sulfate.
Isoxsuprine may cause transient flushing, hypotension tachycardia, rashes and gastrointestinal disturbances. Maternal pulmonary oedema and fetal tachycardia have been reported following intravenous administration in premature labour.
Store at temperatures not exceeding 30°C.
C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative agents. Used as peripheral vasodilators.
Duvaprine tab 10 mg
40's (P450/pack)
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