Durazol Description

Each EC tablet contains: Pantoprazole (as Sodium Sesquihydrate), USP 40 mg.
Pantoprazole (Durazol) is a cream to creamy yellow enteric-coated tablet, oval shaped, biconvex and plain on both sides.
The active ingredient in Pantoprazole for delayed-release tablet is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2[[3,5- dimethoxy-2- pyridinyl)methyl]methyl )sulfinyl] 1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid secretion. Its empirical formula is C₁₆H₁₄F₂N₃NaO₄S x 1.5 H₂O, with a molecular weight of 432.4. Pantoprazole sodium sesquihydrate is a white to off-while crystalline powder and is racemic. Pantoprazole has weakly basic and acidic properties. Pantoprazole sodium sesquihydrate is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane.
Pantoprazole is a proton pump inhibitor. It inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase), the "proton pump" of the gastric parietal cell. It is used in conditions where inhibition of the gastric acid secretion may be beneficial, including aspiration syndromes, dyspepsia, gastro-esophageal reflux disease, peptic ulcer disease and the Zollinger-Ellison syndrome.