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Valsartan: No clinically significant pharmacokinetic interactions were observed when valsartan was co-administered with amlodipine, atenolol, cimetidine, digoxin, furosemide, glibenclamide, hydrochlorothiazide, or indometacin. The valsartan-atenolol combination was more antihypertensive than either agent given alone.
Hydrochlorothiazide: When administered concurrently the following drugs may interact with thiazide diuretics: Potentiation of Alcohol, Barbiturates, or narcotics-potentiation of orthostatic hypotension may occur. Antidiabetic drugs (oral agents and insulin)-Dosage adjustment of the antidiabetic drug may be required.
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