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Pharmacology: As a laxative that acts on the colon,
bisacodyl specifically stimulates the natural evacuation process in the
lower region of the gastrointestinal tract. Therefore, bisacodyl is
ineffective in altering the digestion or absorption of calories or
essential nutrients in the small intestine.
Bisacodyl (Dulcolax) is a locally acting laxative from the diphenylmethane derivatives group.
As a contact laxative, bisacodyl stimulates peristalsis of the colon and
promotes accumulation of water in the colonic lumen which leads to
stimulation of defecation, reduction of transit time and softening of
stool.
The laxative effect of Bisacodyl (Dulcolax) occurs upon contact with the
colonic mucosa where it stimulates the sensory nerve endings that
results to increased peristaltic contractions of the large intestine to
produce soft well-formed stools.
This results in a stimulation of
defecation, reduction of transit time, and a softening of the stool. It
is a reversible reaction wherein colonic function would return to its
normal condition after defecation occurs.
The tablets usually exert a laxative effect within 6-12 hours after
intake. The suppositories usually take effect in about 20 minutes (range
10 to 30 minutes); in some cases, it occurs 45 minutes after
administration.
