Recommended Dosage: The recommended dosage of DROFEPEN is 500 mg administered every 8 hours by intravenous infusion over one hour in patients ≥18 years of age. The recommended dosage and administration by infection is described in Table 2: See Table 2.
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Patients with Renal Impairment: See Table 3.
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The following formula may be used to estimate CrCl. The serum creatinine used in the formula should represent a steady state of renal function. (See equation.)
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Doripenem is hemodialyzable; however, there is insufficient information to make dose adjustment recommendations in patients on hemodialysis.