Drenex Overdosage

As the clinically effective dose of corticosteroids vary according to the indications and requirements of individual patients, it is hardly possible to define "excessive" dosage of corticosteroids and reports of acute toxicity and/or death resulting from corticosteroid over dosage are rare. However, continued use of large doses of corticosteroids (which are often necessary to elicit a clinical response) without proper dose reduction, leads to exaggeration of usual corticosteroid-related problems such as mental symptoms, moon face, abnormal fat deposits, fluid retention, excessive appetite, weight gain, hypertrichosis, acne, striae, ecchymosis, increased sweating, pigmentation, dry scaly skin, thinning scalp hair, increased blood pressure, tachycardia, thrombophlebitis, decreased resistance to infection, negative nitrogen balance with delayed bone and wound healing, headache, weakness, menstrual disorders, accentuated menopausal symptoms, neuropathy, fractures, osteoporosis, peptic ulcer, decreased glucose tolerance, hypokalemia, and adrenal insufficiency.
No specific antidote is available and acute overdosage should be treated immediately by gastric lavage or emesis followed by supportive and symptomatic therapy.