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Methyldopa should be used with caution in patients impaired renal or hepatic function or history of haemolytic anaemia, liver disease, or depression. It should not be given to patients with active liver disease or depression and it is not recommended for phaeochromocytoma.
Patients taking methyldopa may produce a positive response to a direct Coomb's test reaction will aid cross-matching.
Methyldopa may cause sedation. Affected patient is not advisable to drive or operate machinery.
