Dolo-Neurobion 3B Drug Interactions

Vitamin B1, B6 and B12: L-dopa: The effect of L-dopa may be reduced when vitamin B6 is administered concomitantly.
Pyridoxine-antagonists, e.g. isoniazid (INH), cycloserine, penicillamine, hydralazine: The efficacy of vitamin B6 (pyridoxine) may be decreased.
Loop diuretics, e.g. furosemide: The blood level of thiamine (vitamin B1) may be reduced.
Long-term use of acid lowering agents may lead to vitamin B12 deficiency.
Paracetamol: A prolonged regular use of Paracetamol may potentiate the effect of oral anticoagulants (e.g. warfarin).
The risk of Paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes (e.g. anti-epileptics).
Paracetamol decreases the effectiveness of lamotrigine.
Taking Paracetamol + Vitamin B1 + Vitamin B6 + Vitamin B12 (Dolo-Neurobion 3B) Tablet with alcohol increases the concentration of hepatotoxic metabolites in plasma and may lead to hepatotoxicity.