Dolfenal Adverse Reactions

The most frequently reported undesirable effects (1 to 10%) of mefenamic acid include abdominal pain, abnormal kidney function, anemia, constipation, diarrhea, dizziness, dyspepsia, edema, elevated liver enzymes (e.g., alanine transaminase or aspartate transaminase), flatulence, gastrointestinal ulcers (gastric/duodenal), gross bleeding/perforation, headache, heartburn, increased bleeding time, itching, nausea, rashes, ringing in the ears (tinnitus), and vomiting.
Less common undesirable effects (<1% of patients) include:
250 mg: Blood: Abnormal enlargement of the lymph nodes, anemia, bacterial infection in the bloodstream or body tissues (sepsis), black or blue marks or bruises (ecchymosis), decreased hematocrit, low platelet count, low white blood cell count (i.e., leukopenia, neutropenia, agranulocytosis, eosinophilia, pancytopenia), red or purple discoloration of the skin (purpura).
Immune System: Allergic reactions including asthma, breathing difficulty, or skin reactions [e.g., rapid swelling beneath the skin (angioedema), widespread scaling of the skin (exfoliative dermatitis), Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme].
Metabolic: Appetite changes, fluid retention, high blood sugar, low sodium in blood, weight changes.
Psychiatric: Confusion, depression, nervousness.
Nervous System: Anxiety, coma, dream abnormalities, drowsiness, hallucination, inflammation of the meninges (meningitis), inflammation of the optic nerve (optic neuritis), insomnia, loss of strength, numbness or tingling of the skin, seizures, sleepiness, tremors, vertigo.
Special Senses: Blurred vision, ear pain, eye irritation/pain, hearing impairment, inflammation or infection of the membrane lining the eyelids (conjunctivitis), reversible loss of color vision, visual disturbances.
Cardiovascular: Abnormal heart rhythms, congestive heart failure, heart attack, high blood pressure, inflammation of the walls of blood vessels, loss of consciousness, low blood pressure, palpitations, rapid heart rate, stroke.
Lungs: Asthma, breathing difficulty, respiratory depression, pneumonia.
Stomach/Gut: Anorexia, belching, dry mouth, dyspepsia, inflammation of the mucous linings in the mouth, inflammation of the pancreas, inflammation of the stomach, inflammation of the tongue, inflammation or irritation of the esophagus, passing black or bloody stools, passing stools with excess fat, rectal bleeding, vomiting with blood, worsen inflammation of the intestine or colon.
Liver: Abnormal liver function tests, abnormal yellowing of the skin (jaundice), inflammation of the liver (hepatitis), liver damage, liver failure.
Skin: Hair loss, hives, itching, perspiration, photosensitivity, swelling of the face or voice box.
Kidneys: Abnormal kidney function, decreased urine output, excess serum proteins in the urine, increased urine output, inflammation of the kidneys or urinary bladder, inflammation of the spaces between the kidney tubules (interstitial nephritis), kidney failure, pain when urinating, blood in the urine.
Body as a Whole: Death, fatigue, fever, general ill feeling, infection, organ failure.
Investigations: False-positive for bile in the urine.
500 mg: Blood and Lymphatic System: Agranulocytosis, aplastic anemia, bone marrow hypoplasia, decreased hematocrit, disseminated intravascular coagulation, ecchymosis, eosinophilia, hemolytic anemia, leukopenia with a risk or infection, leukopenia, lymphadenopathy, neutropenia, pancytopenia, purpura, sepsis, thrombocytopenia.
Immune System: Hypersensitivity reactions including anaphylaxis, respiratory tract reactivity (e.g., asthma, aggravated asthma, bronchospasm, or dyspnea) or skin reactions (e.g., pruritus, urticaria, purpura, angioedema, exfoliative or bullous dermatoses, SJS, TEN, erythema multiforme).
Metabolism and Nutrition: Appetite changes, fluid retention, glucose intolerance in diabetic patients, hyperglycemia, hyponatremia, weight changes.
Psychiatric: Confusion, depression, nervousness.
Nervous System: Anxiety, aseptic meningitis, asthenia, coma, convulsions, dream abnormalities, drowsiness, insomnia, meningitis, optic neuritis, paresthesia, reversible leukoencephalopathy, somnolence, tremors, vertigo.
Eye Disorders: Blurred vision, conjunctivitis, eye irritation/pain, reversible loss of color vision, visual disturbances.
Ear and Labyrinth: Ear pain, hearing impairment.
Cardiovascular: Arrhythmia, congestive heart failure, hypertension, hypotension, myocardial infarction, palpitations, stroke, syncope, tachycardia, vasculitis.
Respiratory, Thoracic and Mediastinal: Asthma, dyspnea, respiratory depression, pneumonia.
Gastrointestinal: Anorexia, colitis, dry mouth, dyspepsia, enterocolitis, eructation, esophagitis, exacerbation of colitis and Crohn's disease, gastritis, glossitis, hematemesis, melena, pancreatitis, pyrosis, rectal bleeding, steatorrhea, ulcerative stomatitis.
Hepatobiliary: Cholestatic jaundice, hepatic Mime, hepatitis, hepatorenal syndrome, hepatotoxicity.
Skin and Subcutaneous Tissue: Alopecia, exfoliative dermatitis, face edema, laryngeal edema, perspiration, photosensitivity, urticaria.
Renal and Urinary: Acute interstitial nephritis, cystitis, dysuria, glomerulonephritis, hematuria, nephrotic syndrome, non-oliguric renal failure (particularly in dehydration), oliguria/polyuria, proteinuria, renal failure including renal papillary necrosis, tubulointerstitial nephritis.
General Disorders: Death, fatigue, fever, infection, malaise, multi-organ failure.
Investigations: False-positive for bile in the urine.