Doses are usually given in the morning so that sleep is not interrupted by diuresis. Diuresis is initiated in about 2 hours following the oral administration of hydrochlorothiazide, reaches a maximum in about 4 hours, and lasts for 6 to 12 hours. Hydrochlorothiazide is given orally. In the treatment of edema, the usual dose is 25 mg to 100 mg daily, reduced to a dose of 25 mg to 50 mg daily or intermittently; in severe cases, initial dose up to 200 mg daily have been suggested. In the treatment of nephrogenic diabetes insipidus, an initial dose of up to 100mg daily may be employed. In the treatment of hypertension, the usual dose of hydrochlorothiazide is 25 mg to 50 mg daily, either alone or in conjunction with other anti-hypertensives. In some patients an initial dose of 12.5mg may be sufficient. Doses up to 100 mg have been suggested but use rarely.
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